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Sliptin-M 1000 ER Tablet 1 Strip
Sitagliptin + Metformin Hydrochloride is used as an adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus, particularly when treatment with both sitagliptin and metformin is appropriate.
It should not be used in patients with type 1 diabetes or for diabetic ketoacidosis, as it would not be effective in these conditions. It has not been studied in patients with a history of pancreatitis, and the risk of pancreatitis in these patients is unknown.
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✅ Description:
Sliptin-M 1000 ER Tablet combines two antihyperglycemic agents with complementary mechanisms. Sitagliptin, a DPP-4 inhibitor, works by prolonging the activity of incretin hormones like GLP-1 and GIP, which increase insulin secretion and reduce glucagon levels in a glucose-dependent manner. Metformin, a biguanide, lowers blood glucose by reducing hepatic glucose production, decreasing intestinal glucose absorption, and increasing peripheral glucose uptake.
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✔️ Side Effects: Sliptin-M 1000 ER Tablet
Common side effects include diarrhea, upper respiratory tract infections, headache, hypoglycemia (in combination with insulin or sulfonylurea), and nasopharyngitis. Gastrointestinal effects such as nausea, vomiting, and abdominal discomfort are also common with metformin initiation.
✔️ Dosage & Administration: Sliptin-M 1000 ER Tablet
- Film-coated tablet: The dose should be individualized based on the patient's current regimen, effectiveness, and tolerability. The maximum daily dose should not exceed 100 mg of sitagliptin and 2000 mg of metformin.
- For patients not currently on metformin, the starting dose is 50 mg sitagliptin/500 mg metformin twice daily.
- For those already on metformin, the recommended starting dose is 50 mg sitagliptin/1000 mg metformin twice daily.
- Extended-release tablet: Take once daily with a meal, preferably in the evening. Gradually increase the dose to minimize gastrointestinal side effects.
✔️ Interactions: Sliptin-M 1000 ER Tablet
- Cationic drugs eliminated by renal secretion should be used with caution.
- Phenprocoumon: Metformin may decrease its anticoagulant effect, so INR should be monitored.
- Levothyroxine: May reduce metformin's hypoglycemic effect, requiring blood glucose monitoring and possible dose adjustment.
✔️ This tablet should not be used in patients with:
- Renal dysfunction (e.g., serum creatinine ≥1.5 mg/dL in males or ≥1.4 mg/dL in females).
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
- A history of serious hypersensitivity reactions to sitagliptin or metformin.
✔️ Pregnancy & Lactation:
- Pregnancy Category B: No adequate studies have been conducted on pregnant women, so it should only be used if needed.
- It is not known if sitagliptin is excreted in human milk, so caution is advised for nursing women.
✔️ Precautions & Warnings:
- Lactic Acidosis: Metformin accumulation can cause lactic acidosis, especially in patients with renal impairment, sepsis, dehydration, or excessive alcohol intake. Discontinue the medication immediately if acidosis is suspected.
- Hematologic Monitoring: Annual monitoring is recommended.
- Pancreatitis: Discontinue if pancreatitis is suspected.
- Renal Function: Monitor renal function regularly.
✔️ Storage:
Store below 25°C, in a dry place, away from light, and out of the reach of children. Do not use after the expiration date. To be dispensed only on a prescription from a registered physician.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
